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A novel SOD mimic with a redox-modulating mn (II) complex, ML1 attenuates high glucose-induced abnormalities in intracellular Ca(2+) transients and prevents cardiac cell death through restoration of mitochondrial function
A key contributor to the pathophysiology of diabetic cardiomyopathy, mitochondrial superoxide can be adequately countered by Mn-superoxide dismutase, which constitutes the first line of defense against mitochondrial oxidative stress. Our group has recently synthesized low molecular weight SOD mimics...
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| Udgivet i: | Biochem Biophys Rep |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5600348/ https://ncbi.nlm.nih.gov/pubmed/28955837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2016.01.003 |
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