The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation

As a central regulator of cell polarity, the activity of CDC42 GTPase is tightly controlled in maintaining normal hematopoietic stem and progenitor cell (HSC/P) functions. We found that transformation of HSC/P to acute myeloid leukemia (AML) is associated with increased CDC42 expression and activity...

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Vydáno v:Blood
Hlavní autoři: Mizukawa, Benjamin, O’Brien, Eric, Moreira, Daniel C., Wunderlich, Mark, Hochstetler, Cindy L., Duan, Xin, Liu, Wei, Orr, Emily, Grimes, H. Leighton, Mulloy, James C., Zheng, Yi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2017
Témata:
Myeloid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600140/
https://ncbi.nlm.nih.gov/pubmed/28778865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-12-758458
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