Fission Yeast Polarization: Modeling Cdc42 Oscillations, Symmetry Breaking, and Zones of Activation and Inhibition

Cells polarize for growth, motion, or mating through regulation of membrane-bound small GTPases between active GTP-bound and inactive GDP-bound forms. Activators (GEFs, GTP exchange factors) and inhibitors (GAPs, GTPase activating proteins) provide positive and negative feedbacks. We show that a rea...

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Main Authors: Bita Khalili, Hailey D. Lovelace, David M. Rutkowski, Danielle Holz, Dimitrios Vavylonis
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2020-07-01
Series:Cells
Assuntos:
cell polarization
mathematical model
fission yeast
reaction–diffusion model
small GTPases
Cdc42 oscillations
Acceso en liña:https://www.mdpi.com/2073-4409/9/8/1769
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