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Effect of Food Intake on the Pharmacodynamics of Tenapanor: A Phase 1 Study

Tenapanor (RDX5791/AZD1722) is a minimally systemic small‐molecule inhibitor of the sodium/hydrogen exchanger NHE3. Tenapanor acts in the gut to reduce absorption of sodium and phosphate. This phase 1 open‐label, 3‐way crossover study (NCT02226783) evaluated the effect of food on the pharmacodynamic...

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Bibliografske podrobnosti
izdano v:Clin Pharmacol Drug Dev
Main Authors: Johansson, Susanne A., Knutsson, Mikael, Leonsson‐Zachrisson, Maria, Rosenbaum, David P.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599956/
https://ncbi.nlm.nih.gov/pubmed/28339149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpdd.341
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