Identification of Vaccinia Virus Replisome and Transcriptome Proteins by Isolation of Proteins on Nascent DNA Coupled with Mass Spectrometry

Poxviruses replicate within the cytoplasm and encode proteins for DNA and mRNA synthesis. To investigate poxvirus replication and transcription from a new perspective, we incorporated 5-ethynyl-2′-deoxyuridine (EdU) into nascent DNA in cells infected with vaccinia virus (VACV). The EdU-labeled DNA w...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Senkevich, Tatiana G., Katsafanas, George C., Weisberg, Andrea, Olano, Lisa R., Moss, Bernard
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2017
Sujets:
Genome Replication and Regulation of Viral Gene Expression
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599757/
https://ncbi.nlm.nih.gov/pubmed/28747503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01015-17
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