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Caloric restriction delays age-related methylation drift

In mammals, caloric restriction consistently results in extended lifespan. Epigenetic information encoded by DNA methylation is tightly regulated, but shows a striking drift associated with age that includes both gains and losses of DNA methylation at various sites. Here, we report that epigenetic d...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Maegawa, Shinji, Lu, Yue, Tahara, Tomomitsu, Lee, Justin T., Madzo, Jozef, Liang, Shoudan, Jelinek, Jaroslav, Colman, Ricki J., Issa, Jean-Pierre J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599616/
https://ncbi.nlm.nih.gov/pubmed/28912502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00607-3
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