Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1α

The generation of functional arterial endothelial cells (aECs) from embryonic stem cells (ESCs) holds great promise for vascular tissue engineering. However, the mechanisms underlying their generation and the potential of aECs in revascularizing ischemic tissue are not fully understood. Here, we obs...

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Vydáno v:Stem Cell Reports
Hlavní autoři: Tsang, Kit Man, Hyun, James S., Cheng, Kwong Tai, Vargas, Micaela, Mehta, Dolly, Ushio-Fukai, Masuko, Zou, Li, Pajcini, Kostandin V., Rehman, Jalees, Malik, Asrar B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599266/
https://ncbi.nlm.nih.gov/pubmed/28781077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.07.001
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