A Tie2-Notch1 signaling axis regulates regeneration of the endothelial bone marrow niche

Loss-of-function studies have determined that Notch signaling is essential for hematopoietic and endothelial development. By deleting a single allele of the Notch1 transcriptional activation domain we generated viable, post-natal mice exhibiting hypomorphic Notch signaling. These heterozygous mice,...

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Publicat a:Haematologica
Autors principals: Shao, Lijian, Sottoriva, Kilian, Palasiewicz, Karol, Zhang, Jizhou, Hyun, James, Soni, Sweta S., Paik, Na Yoon, Gao, Xiaopei, Cuervo, Henar, Malik, Asrar B., Rehman, Jalees, Lucas, Daniel, Pajcini, Kostandin V.
Format: Artigo
Idioma:Inglês
Publicat: Ferrata Storti Foundation 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6821596/
https://ncbi.nlm.nih.gov/pubmed/30923091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.208660
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