Rapid Generation of Human Genetic Loss-of-Function iPSC Lines by Simultaneous Reprogramming and Gene Editing

Specifically ablating genes in human induced pluripotent stem cells (iPSCs) allows for studies of gene function as well as disease mechanisms in disorders caused by loss-of-function (LOF) mutations. While techniques exist for engineering such lines, we have developed and rigorously validated a metho...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Tidball, Andrew M., Dang, Louis T., Glenn, Trevor W., Kilbane, Emma G., Klarr, Daniel J., Margolis, Joshua L., Uhler, Michael D., Parent, Jack M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599229/
https://ncbi.nlm.nih.gov/pubmed/28781079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.07.003
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