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ADAR1-dependent RNA editing promotes MET and iPSC reprogramming by alleviating ER stress
RNA editing of adenosine to inosine (A-to-I) is catalyzed by ADAR1 and dramatically alters the cellular transcriptome, although its functional roles in somatic cell reprogramming are largely unexplored. Here we show that loss of ADAR1-mediated A-to-I editing disrupts mesenchymal-to-epithelial transi...
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| Pubblicato in: | Cell Stem Cell |
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| Autori principali: | , , , , , , , , , , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7415614/ https://ncbi.nlm.nih.gov/pubmed/32396862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.04.016 |
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