ADAR1-dependent RNA editing promotes MET and iPSC reprogramming by alleviating ER stress

RNA editing of adenosine to inosine (A-to-I) is catalyzed by ADAR1 and dramatically alters the cellular transcriptome, although its functional roles in somatic cell reprogramming are largely unexplored. Here we show that loss of ADAR1-mediated A-to-I editing disrupts mesenchymal-to-epithelial transi...

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Pubblicato in:Cell Stem Cell
Autori principali: Guallar, Diana, Fuentes-Iglesias, Alejandro, Souto, Yara, Ameneiro, Cristina, Freire-Agulleiro, Oscar, Pardavila, Jose Angel, Escudero, Adriana, Garcia-Outeiral, Vera, Moreira, Tiago, Saenz, Carmen, Xiong, Heng, Liu, Dongbing, Xiao, Shidi, Hou, Yong, Wu, Kui, Torrecilla, Daniel, Hartner, Jochen C., Blanco, Miguel G., Lee, Leo J, López, Miguel, Walkley, Carl R., Wang, Jianlong, Fidalgo, Miguel
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415614/
https://ncbi.nlm.nih.gov/pubmed/32396862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.04.016
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