Soluble NKG2D ligands in the ovarian cancer microenvironment are associated with an adverse clinical outcome and decreased memory effector T cells independent of NKG2D downregulation

The immune receptor NKG2D is predominantly expressed on NK cells and T cell subsets and confers anti-tumor activity. According to the current paradigm, immune surveillance is counteracted by soluble ligands shed into the microenvironment, which down-regulate NKG2D receptor expression. Here, we analy...

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Vydáno v:Oncoimmunology
Hlavní autoři: Vyas, Maulik, Reinartz, Silke, Hoffmann, Nathalie, Reiners, Katrin S., Lieber, Sonja, Jansen, Julia M., Wagner, Uwe, Müller, Rolf, von Strandmann, Elke Pogge
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2017
Témata:
Brief Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599084/
https://ncbi.nlm.nih.gov/pubmed/28932639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1339854
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