Local endothelial complement activation reverses endothelial quiescence, enabling t-cell homing, and tumor control during t-cell immunotherapy

Cancer immunotherapy relies upon the ability of T cells to infiltrate tumors. The endothelium constitutes a barrier between the tumor and effector T cells, and the ability to manipulate local vascular permeability could be translated into effective immunotherapy. Here, we show that in the context of...

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Publicado en:Oncoimmunology
Autores principales: Facciabene, Andrea, De Sanctis, Francesco, Pierini, Stefano, Reis, Edimara S., Balint, Klara, Facciponte, John, Rueter, Jens, Kagabu, Masahiro, Magotti, Paola, Lanitis, Evripidis, DeAngelis, Robert A., Buckanovich, Ronald J., Song, Wenchao C., Lambris, John D., Coukos, George
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2017
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599081/
https://ncbi.nlm.nih.gov/pubmed/28932632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1326442
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