Tumor endothelial marker 1–specific DNA vaccination targets tumor vasculature

Tumor endothelial marker 1 (TEM1; also known as endosialin or CD248) is a protein found on tumor vasculature and in tumor stroma. Here, we tested whether TEM1 has potential as a therapeutic target for cancer immunotherapy by immunizing immunocompetent mice with Tem1 cDNA fused to the minimal domain...

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Detalhes bibliográficos
Main Authors: Facciponte, John G., Ugel, Stefano, De Sanctis, Francesco, Li, Chunsheng, Wang, Liping, Nair, Gautham, Sehgal, Sandy, Raj, Arjun, Matthaiou, Efthymia, Coukos, George, Facciabene, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973096/
https://ncbi.nlm.nih.gov/pubmed/24642465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67382
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