Genetic and Pharmacologic Inhibition of Complement Impairs Endothelial Cell Function and Ablates Ovarian Cancer Neovascularization

Complement activation plays a critical role in controlling inflammatory responses. To assess the role of complement during ovarian cancer progression, we crossed two strains of mice with genetic complement deficiencies with transgenic mice that develop epithelial ovarian cancer (TgMISIIR-TAg). TgMIS...

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Detalhes bibliográficos
Main Authors: Nunez-Cruz, Selene, Gimotty, Phyllis A, Guerra, Matthew W, Connolly, Denise C, Wu, You-Qiang, DeAngelis, Robert A, Lambris, John D, Coukos, George, Scholler, Nathalie
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514739/
https://ncbi.nlm.nih.gov/pubmed/23226093
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