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Effect of iron overload on furin expression in wild-type and β-thalassemic mice
Furin is a proprotein convertase enzyme. In the liver, it cleaves prohepcidin to form active hepcidin-25, which regulates systemic iron homeostasis. Hepcidin deficiency is a component of several iron overload disorders, including β-thalassemia. Several studies have identified factors that repress he...
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| Publicado no: | Toxicol Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5598392/ https://ncbi.nlm.nih.gov/pubmed/28962376 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxrep.2015.01.004 |
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