Potential toxicity of quercetin: The repression of mitochondrial copy number via decreased POLG expression and excessive TFAM expression in irradiated murine bone marrow

The cytotoxicity of quercetin is not well understood. Using an ICR murine model, we unexpectedly found that mice exposed to 7 Gy total body irradiation (TBI) exhibited general in vivo toxicity after receiving quercetin (100 mg/kg PO), whereas this result was not observed in mice that received TBI on...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Toxicol Rep
Κύριοι συγγραφείς: Chen, Ruiqing, Lin, Jingan, Hong, Jingshen, Han, Deping, Zhang, Addison D., Lan, Ruilong, Fu, Lengxi, Wu, Zhaoyang, Lin, Jianhua, Zhang, Weijian, Wang, Zeng, Chen, Wei, Chen, Chun, Zhang, Hengshan
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Elsevier 2014
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5598249/
https://ncbi.nlm.nih.gov/pubmed/28962259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxrep.2014.07.014
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