Potential toxicity of quercetin: The repression of mitochondrial copy number via decreased POLG expression and excessive TFAM expression in irradiated murine bone marrow

The cytotoxicity of quercetin is not well understood. Using an ICR murine model, we unexpectedly found that mice exposed to 7 Gy total body irradiation (TBI) exhibited general in vivo toxicity after receiving quercetin (100 mg/kg PO), whereas this result was not observed in mice that received TBI on...

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Veröffentlicht in:Toxicol Rep
Hauptverfasser: Chen, Ruiqing, Lin, Jingan, Hong, Jingshen, Han, Deping, Zhang, Addison D., Lan, Ruilong, Fu, Lengxi, Wu, Zhaoyang, Lin, Jianhua, Zhang, Weijian, Wang, Zeng, Chen, Wei, Chen, Chun, Zhang, Hengshan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5598249/
https://ncbi.nlm.nih.gov/pubmed/28962259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxrep.2014.07.014
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