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Reconciling Intermediates in Mechanical Unfolding Experiments With Two-State Protein Folding in Bulk

Most experimentally well-characterized single domain proteins of less than 100 residues have been found to be two-state folders. That is, only two distinct populations can explain both equilibrium and kinetic measurements. Results from single molecule force spectroscopy, where a protein is unfolded...

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Detalhes bibliográficos
Publicado no:J Phys Chem Lett
Main Authors: de Sancho, David, Best, Robert B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5597958/
https://ncbi.nlm.nih.gov/pubmed/27626458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpclett.6b01722
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