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Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors
The absence of an adequate reversal strategy to prevent and stop potential life-threatening bleeding complications is a major drawback to the clinical use of the direct oral inhibitors of blood coagulation factor Xa. Here we show that specific modifications of the substrate-binding aromatic S4 subpo...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5597622/ https://ncbi.nlm.nih.gov/pubmed/28904343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00647-9 |
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