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Blood coagulation factor Va's key interactive residues and regions for prothrombinase assembly and prothrombin binding

Blood coagulation factor Va serves an indispensable role in hemostasis as cofactor for the serine protease factor Xa. In the presence of an anionic phospholipid membrane and calcium ions, factors Va and Xa assemble into the prothrombinase complex. Following formation of the ternary complex with the...

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Bibliographic Details
Published in:J Thromb Haemost
Main Authors: Schreuder, Mark, Reitsma, Pieter H., Bos, Mettine H. A.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851895/
https://ncbi.nlm.nih.gov/pubmed/31102425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14487
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