Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells

α-synuclein-induced neurotoxicity is a core pathogenic event in neurodegenerative synucleinopathies such as Parkinson’s disease, dementia with Lewy bodies, or multiple system atrophy. There is currently no disease-modifying therapy available for these diseases. We screened 1,600 FDA-approved drugs f...

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Pubblicato in:Sci Rep
Autori principali: Höllerhage, Matthias, Moebius, Claudia, Melms, Johannes, Chiu, Wei-Hua, Goebel, Joachim N., Chakroun, Tasnim, Koeglsperger, Thomas, Oertel, Wolfgang H., Rösler, Thomas W., Bickle, Marc, Höglinger, Günter U.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5597612/
https://ncbi.nlm.nih.gov/pubmed/28904388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11664-5
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