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Synthesis and In Vitro and In Vivo Evaluation of [(3)H]LRRK2-IN-1 as a Novel Radioligand for LRRK2
PURPOSE: LRRK2 (leucine-rich repeat kinase 2) has recently been proven to be a promising drug target for Parkinson’s disease (PD) due to an apparent enhanced activity caused by mutations associated with familial PD. To date, there have been no reports in which a LRRK2 inhibitor has been radiolabeled...
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| Publicado en: | Mol Imaging Biol |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5597475/ https://ncbi.nlm.nih.gov/pubmed/28289968 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11307-017-1070-1 |
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