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Manganese-induced trafficking and turnover of GPP130 is mediated by sortilin
Elevated, nontoxic doses of manganese (Mn) protect against Shiga toxin-1–induced cell death via down-regulation of GPP130, a cycling Golgi membrane protein that serves as an endosome-to-Golgi trafficking receptor for the toxin. Mn binds to GPP130 in the Golgi and causes GPP130 to oligomerize/aggrega...
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| Опубликовано в: : | Mol Biol Cell |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The American Society for Cell Biology
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5597328/ https://ncbi.nlm.nih.gov/pubmed/28768823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-05-0326 |
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