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Manganese induces oligomerization to promote down-regulation of the intracellular trafficking receptor used by Shiga toxin

Manganese (Mn) protects cells against lethal doses of purified Shiga toxin by causing the degradation of the cycling transmembrane protein GPP130, which the toxin uses as a trafficking receptor. Mn-induced GPP130 down-regulation, in addition to being a potential therapeutic approach against Shiga to...

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Bibliografische gegevens
Gepubliceerd in:Mol Biol Cell
Hoofdauteurs: Tewari, Ritika, Jarvela, Timothy, Linstedt, Adam D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Cell Biology 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230593/
https://ncbi.nlm.nih.gov/pubmed/25079690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-05-1003
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