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Manganese induces oligomerization to promote down-regulation of the intracellular trafficking receptor used by Shiga toxin

Manganese (Mn) protects cells against lethal doses of purified Shiga toxin by causing the degradation of the cycling transmembrane protein GPP130, which the toxin uses as a trafficking receptor. Mn-induced GPP130 down-regulation, in addition to being a potential therapeutic approach against Shiga to...

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Publicado en:Mol Biol Cell
Main Authors: Tewari, Ritika, Jarvela, Timothy, Linstedt, Adam D.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Cell Biology 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230593/
https://ncbi.nlm.nih.gov/pubmed/25079690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-05-1003
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