Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single Step Transformation by KRAS Mutations

We define how chronic cigarette smoke-induced time-dependent epigenetic alterations can sensitize human bronchial epithelial cells for transformation by a single oncogene. The smoke-induced chromatin changes include initial repressive polycomb marking of genes, later manifesting abnormal DNA methyla...

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Vydáno v:Cancer Cell
Hlavní autoři: Vaz, Michelle, Hwang, Stephen Y, Kagiampakis, Ioannis, Phallen, Jillian, Patil, Ashwini, O’Hagan, Heather M, Murphy, Lauren, Zahnow, Cynthia A, Gabrielson, Edward, Velculescu, Victor E, Easwaran, Hariharan P, Baylin, Stephen B
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596892/
https://ncbi.nlm.nih.gov/pubmed/28898697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.08.006
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