Mechanistic Multi—Tissue Modeling of Glucocorticoid-Induced Leucine Zipper Regulation: Integrating Circadian Gene Expression with Receptor-Mediated Corticosteroid Pharmacodynamics

The glucocorticoid-induced leucine zipper (GILZ) is an important mediator of anti-inflammatory corticosteroid action. The pharmacokinetic/pharmacodynamic/pharmacogenomic effects of acute and chronic methylprednisolone (MPL) dosing on the tissue-specific dynamics of GILZ expression were examined in r...

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Bibliografische gegevens
Gepubliceerd in:J Pharmacol Exp Ther
Hoofdauteurs: Ayyar, Vivaswath S., DuBois, Debra C., Almon, Richard R., Jusko, William J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Pharmacology and Experimental Therapeutics 2017
Onderwerpen:
Metabolism, Transport, and Pharmacogenomics
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596815/
https://ncbi.nlm.nih.gov/pubmed/28729456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.242990
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