Uev1A facilitates osteosarcoma differentiation by promoting Smurf1-mediated Smad1 ubiquitination and degradation

Malignant bone tumor osteosarcoma (OS) displays high metastasis incidence and poor prognosis. Its stem cell properties could serve to explain tumor recurrence and resistance to conventional treatments. In this study, we identified UEV1A as a novel suppressor of OS. Elevated UEV1A diminishes stem cel...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Zhang, Weiwei, Zhuang, Yuan, Zhang, Yiran, Yang, Xiaoran, Zhang, Hong, Wang, Guifen, Yin, Wanqi, Wang, Ruifeng, Zhang, Zhiling, Xiao, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596555/
https://ncbi.nlm.nih.gov/pubmed/28771228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.366
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