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Smurf1 inhibits integrin activation by controlling Kindlin-2 ubiquitination and degradation
Integrin activation is an indispensable step for various integrin-mediated biological functions. Kindlin-2 is known to coactivate integrins with Talin; however, molecules that restrict integrin activation are elusive. Here, we demonstrate that the E3 ubiquitin ligase Smurf1 controls the amount of Ki...
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| Publicado no: | J Cell Biol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5412569/ https://ncbi.nlm.nih.gov/pubmed/28408404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201609073 |
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