Focal adhesion molecule Kindlin-1 mediates activation of TGF-β signaling by interacting with TGF-βRI, SARA and Smad3 in colorectal cancer cells

Kindlin-1, an integrin-interacting protein, has been implicated in TGF-β/Smad3 signaling. However, the molecular mechanism underlying Kindlin-1 regulation of TGF-β/Smad3 signaling remains elusive. Here, we reported that Kindlin-1 is an important mediator of TGF-β/Smad3 signaling by showing that Kind...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Kong, Jinfeng, Du, Juan, Wang, Yunling, Yang, Mingzi, Gao, Jianchao, Wei, Xiaofan, Fang, Weigang, Zhan, Jun, Zhang, Hongquan
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342809/
https://ncbi.nlm.nih.gov/pubmed/27776350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12779
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