Uev1A facilitates osteosarcoma differentiation by promoting Smurf1-mediated Smad1 ubiquitination and degradation

Malignant bone tumor osteosarcoma (OS) displays high metastasis incidence and poor prognosis. Its stem cell properties could serve to explain tumor recurrence and resistance to conventional treatments. In this study, we identified UEV1A as a novel suppressor of OS. Elevated UEV1A diminishes stem cel...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Death Dis
Auteurs principaux: Zhang, Weiwei, Zhuang, Yuan, Zhang, Yiran, Yang, Xiaoran, Zhang, Hong, Wang, Guifen, Yin, Wanqi, Wang, Ruifeng, Zhang, Zhiling, Xiao, Wei
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2017
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596555/
https://ncbi.nlm.nih.gov/pubmed/28771228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.366
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