p53-mediated suppression of BiP triggers BIK-induced apoptosis during prolonged endoplasmic reticulum stress

Physiological and pathological conditions that affect the folding capacity of the endoplasmic reticulum (ER) provoke ER stress and trigger the unfolded protein response (UPR). The UPR aims to either restore the balance between newly synthesized and misfolded proteins or if the damage is severe, to t...

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Bibliografiske detaljer
Udgivet i:Cell Death Differ
Main Authors: López, Ignacio, Tournillon, Anne-Sophie, Prado Martins, Rodrigo, Karakostis, Konstantinos, Malbert-Colas, Laurence, Nylander, Karin, Fåhraeus, Robin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596431/
https://ncbi.nlm.nih.gov/pubmed/28622297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.96
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