p53-mediated suppression of BiP triggers BIK-induced apoptosis during prolonged endoplasmic reticulum stress

Physiological and pathological conditions that affect the folding capacity of the endoplasmic reticulum (ER) provoke ER stress and trigger the unfolded protein response (UPR). The UPR aims to either restore the balance between newly synthesized and misfolded proteins or if the damage is severe, to t...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: López, Ignacio, Tournillon, Anne-Sophie, Prado Martins, Rodrigo, Karakostis, Konstantinos, Malbert-Colas, Laurence, Nylander, Karin, Fåhraeus, Robin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596431/
https://ncbi.nlm.nih.gov/pubmed/28622297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.96
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