TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis

Recent studies have suggested increased plasticity of differentiated cells within the intestine to act both as intestinal stem cells (ISCs) and tumour-initiating cells. However, little is known of the processes that regulate this plasticity. Our previous work has shown that activating mutations of K...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Cell Death Differ
المؤلفون الرئيسيون: Cammareri, Patrizia, Vincent, David F, Hodder, Michael C, Ridgway, Rachel A, Murgia, Claudio, Nobis, Max, Campbell, Andrew D, Varga, Julia, Huels, David J, Subramani, Chithra, Prescott, Katie L H, Nixon, Colin, Hedley, Ann, Barry, Simon T, Greten, Florian R, Inman, Gareth J, Sansom, Owen J
التنسيق: Artigo
اللغة:Inglês
منشور في: Nature Publishing Group 2017
الموضوعات:
Original Paper
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596428/
https://ncbi.nlm.nih.gov/pubmed/28622298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.92
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