Acetyl-4′-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency

Coenzyme A is an essential metabolite known for its central role in over one hundred cellular metabolic reactions. In cells, Coenzyme A is synthesized de novo in five enzymatic steps with vitamin B5 as the starting metabolite, phosphorylated by pantothenate kinase. Mutations in the pantothenate kina...

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Publicado no:Sci Rep
Main Authors: Di Meo, Ivano, Colombelli, Cristina, Srinivasan, Balaji, de Villiers, Marianne, Hamada, Jeffrey, Jeong, Suh Y., Fox, Rachel, Woltjer, Randall L., Tepper, Pieter G., Lahaye, Liza L., Rizzetto, Emanuela, Harrs, Clara H., de Boer, Theo, van der Zwaag, Marianne, Jenko, Branko, Čusak, Alen, Pahor, Jerca, Kosec, Gregor, Grzeschik, Nicola A., Hayflick, Susan J., Tiranti, Valeria, Sibon, Ody C. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5595861/
https://ncbi.nlm.nih.gov/pubmed/28900161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11564-8
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