Pantethine rescues a Drosophila model for pantothenate kinase–associated neurodegeneration

Pantothenate kinase–associated neurodegeneration (PKAN), a progressive neurodegenerative disorder, is associated with impairment of pantothenate kinase function. Pantothenate kinase is the first enzyme required for de novo synthesis of CoA, an essential metabolic cofactor. The pathophysiology of PKA...

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Detalhes bibliográficos
Main Authors: Rana, Anil, Seinen, Erwin, Siudeja, Katarzyna, Muntendam, Remco, Srinivasan, Balaji, van der Want, Johannes J., Hayflick, Susan, Reijngoud, Dirk-Jan, Kayser, Oliver, Sibon, Ody C. M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872433/
https://ncbi.nlm.nih.gov/pubmed/20351285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912105107
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