Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration

Pantothenate kinase-associated neurodegeneration (PKAN is a neurodegenerative disease with unresolved pathophysiology. Previously, we observed reduced Coenzyme A levels in a Drosophila model for PKAN. Coenzyme A is required for acetyl-Coenzyme A synthesis and acyl groups from the latter are transfer...

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Main Authors: Siudeja, Katarzyna, Srinivasan, Balaji, Xu, Lanjun, Rana, Anil, de Jong, Jannie, Nollen, Ellen A A, Jackowski, Suzanne, Sanford, Lynn, Hayflick, Susan, Sibon, Ody C M
Format: Artigo
Jezik:Inglês
Izdano: WILEY-VCH Verlag 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377114/
https://ncbi.nlm.nih.gov/pubmed/21998097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201100180
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