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Montelukast reduces inhaled chlorine triggered airway hyperresponsiveness and airway inflammation in the mouse

BACKGROUND AND PURPOSE: Cysteinyl leukotrienes (CysLTs) are pro‐inflammatory lipid mediators that exacerbate disease state in several asthma phenotypes including asthma induced by allergen, virus and exercise. However, the role of CysLTs in irritant‐induced airway disease is not well characterized....

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Foilsithe in:Br J Pharmacol
Main Authors: Hamamoto, Yoichiro, Ano, Satoshi, Allard, Benoit, O'Sullivan, Michael, McGovern, Toby K, Martin, James G
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5595758/
https://ncbi.nlm.nih.gov/pubmed/28718891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13953
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