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Montelukast reduces inhaled chlorine triggered airway hyperresponsiveness and airway inflammation in the mouse

BACKGROUND AND PURPOSE: Cysteinyl leukotrienes (CysLTs) are pro‐inflammatory lipid mediators that exacerbate disease state in several asthma phenotypes including asthma induced by allergen, virus and exercise. However, the role of CysLTs in irritant‐induced airway disease is not well characterized....

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Publicado en:Br J Pharmacol
Autores principales: Hamamoto, Yoichiro, Ano, Satoshi, Allard, Benoit, O'Sullivan, Michael, McGovern, Toby K, Martin, James G
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5595758/
https://ncbi.nlm.nih.gov/pubmed/28718891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13953
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