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Methylation of the ribosomal RNA gene promoter is associated with aging and age‐related decline

The transcription of ribosomal RNA genes (rDNA) is subject to epigenetic regulation, as it is abrogated by the methylation of CpG dinucleotides within their promoter region. Here, we investigated, through Sequenom platform, the age‐related methylation status of the CpG island falling into the rDNA p...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: D'Aquila, Patrizia, Montesanto, Alberto, Mandalà, Maurizio, Garasto, Sabrina, Mari, Vincenzo, Corsonello, Andrea, Bellizzi, Dina, Passarino, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5595699/
https://ncbi.nlm.nih.gov/pubmed/28625020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12603
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