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A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres

DNA double-strand breaks (DSBs) and short telomeres are structurally similar, yet they have diametrically opposed fates. Cells must repair DSBs while blocking the action of telomerase on these ends. Short telomeres must avoid recognition by the DNA damage response while promoting telomerase recruitm...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Strecker, Jonathan, Stinus, Sonia, Caballero, Mariana Pliego, Szilard, Rachel K, Chang, Michael, Durocher, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5595431/
https://ncbi.nlm.nih.gov/pubmed/28826474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23783
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