TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses

Toll-like receptor (TLR)-mediated signaling are critical for host defense against pathogen invasion. However, excessive responses would cause harmful damages to the host. Here we show that deficiency of the E3 ubiquitin ligase TRIM32 increases poly(I:C)- and LPS-induced transcription of downstream g...

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Publicado en:PLoS Pathog
Autores principales: Yang, Qing, Liu, Tian-Tian, Lin, Heng, Zhang, Man, Wei, Jin, Luo, Wei-Wei, Hu, Yun-Hong, Zhong, Bo, Hu, Ming-Ming, Shu, Hong-Bing
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5595311/
https://ncbi.nlm.nih.gov/pubmed/28898289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006600
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