TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses

Toll-like receptor (TLR)-mediated signaling are critical for host defense against pathogen invasion. However, excessive responses would cause harmful damages to the host. Here we show that deficiency of the E3 ubiquitin ligase TRIM32 increases poly(I:C)- and LPS-induced transcription of downstream g...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Yang, Qing, Liu, Tian-Tian, Lin, Heng, Zhang, Man, Wei, Jin, Luo, Wei-Wei, Hu, Yun-Hong, Zhong, Bo, Hu, Ming-Ming, Shu, Hong-Bing
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5595311/
https://ncbi.nlm.nih.gov/pubmed/28898289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006600
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados