Rescue of exhausted CD8 T cells by PD-1 targeted therapies is CD28-dependent

Programmed cell death-1 (PD-1) targeted therapies enhance T cell responses and show efficacy in multiple cancers but the role of costimulatory molecules in this T cell rescue remains elusive. Here we demonstrate that the CD28/B7 costimulatory pathway is essential for effective PD-1 therapy during ch...

詳細記述

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書誌詳細
出版年:Science
主要な著者: Kamphorst, Alice O., Wieland, Andreas, Nasti, Tahseen, Yang, Shu, Zhang, Ruan, Barber, Daniel L., Konieczny, Bogumila T., Daugherty, Candace Z., Koenig, Lydia, Yu, Ke, Sica, Gabriel L., Sharpe, Arlene H., Freeman, Gordon J., Blazar, Bruce R., Turka, Laurence A., Owonikoko, Taofeek K., Pillai, Rathi N., Ramalingam, Suresh S., Araki, Koichi, Ahmed, Rafi
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5595217/
https://ncbi.nlm.nih.gov/pubmed/28280249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf0683
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