Rescue of exhausted CD8 T cells by PD-1 targeted therapies is CD28-dependent

Programmed cell death-1 (PD-1) targeted therapies enhance T cell responses and show efficacy in multiple cancers but the role of costimulatory molecules in this T cell rescue remains elusive. Here we demonstrate that the CD28/B7 costimulatory pathway is essential for effective PD-1 therapy during ch...

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Publicado en:Science
Main Authors: Kamphorst, Alice O., Wieland, Andreas, Nasti, Tahseen, Yang, Shu, Zhang, Ruan, Barber, Daniel L., Konieczny, Bogumila T., Daugherty, Candace Z., Koenig, Lydia, Yu, Ke, Sica, Gabriel L., Sharpe, Arlene H., Freeman, Gordon J., Blazar, Bruce R., Turka, Laurence A., Owonikoko, Taofeek K., Pillai, Rathi N., Ramalingam, Suresh S., Araki, Koichi, Ahmed, Rafi
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5595217/
https://ncbi.nlm.nih.gov/pubmed/28280249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf0683
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