Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1–targeted therapy in lung cancer patients

Exhausted T cells in chronic infections and cancer have sustained expression of the inhibitory receptor programmed cell death 1 (PD-1). Therapies that block the PD-1 pathway have shown promising clinical results in a significant number of advanced-stage cancer patients. Nonetheless, a better underst...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kamphorst, Alice O., Pillai, Rathi N., Yang, Shu, Nasti, Tahseen H., Akondy, Rama S., Wieland, Andreas, Sica, Gabriel L., Yu, Ke, Koenig, Lydia, Patel, Nikita T., Behera, Madhusmita, Wu, Hong, McCausland, Megan, Chen, Zhengjia, Zhang, Chao, Khuri, Fadlo R., Owonikoko, Taofeek K., Ahmed, Rafi, Ramalingam, Suresh S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441721/
https://ncbi.nlm.nih.gov/pubmed/28446615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705327114
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