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Prion protein β2–α2 loop conformational landscape

In transmissible spongiform encephalopathies (TSEs), which are lethal neurodegenerative diseases that affect humans and a wide range of other mammalian species, the normal “cellular” prion protein ([Formula: see text]) is transformed into amyloid aggregates representing the “scrapie form” of the pro...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Caldarulo, Enrico, Barducci, Alessandro, Wüthrich, Kurt, Parrinello, Michele
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2017
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594700/
https://ncbi.nlm.nih.gov/pubmed/28827331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1712155114
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