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MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis
Mixed-lineage kinase domain-like protein (MLKL) is essential for TNF-α–induced necroptosis. How MLKL promotes cell death is still under debate. Here we report that MLKL forms SDS-resistant, disulfide bond-dependent polymers during necroptosis in both human and mouse cells. MLKL polymers are independ...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5594682/ https://ncbi.nlm.nih.gov/pubmed/28827318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707531114 |
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