Necroptosis-blocking compound NBC1 targets heat shock protein 70 to inhibit MLKL polymerization and necroptosis

Necroptosis is a regulated necrotic cell death pathway involved in development and disease. Its signaling cascade results in the formation of disulfide bond-dependent amyloid-like polymers of mixed lineage kinase domain-like protein (MLKL), which mediate proinflammatory cell membrane disruption. We...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Johnston, Andrea N., Ma, Yuyong, Liu, Hua, Liu, Shuzhen, Hanna-Addams, Sarah, Chen, She, Chen, Chuo, Wang, Zhigao
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104336/
https://ncbi.nlm.nih.gov/pubmed/32156734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1916503117
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