Stalled replication forks generate a distinct mutational signature in yeast

Proliferating cells acquire genome alterations during the act of DNA replication. This leads to mutation accumulation and somatic cell mosaicism in multicellular organisms, and is also implicated as an underlying cause of aging and tumorigenesis. The molecular mechanisms of DNA replication-associate...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Larsen, Nicolai B., Liberti, Sascha E., Vogel, Ivan, Jørgensen, Signe W., Hickson, Ian D., Mankouri, Hocine W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2017
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594675/
https://ncbi.nlm.nih.gov/pubmed/28827358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706640114
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