Stalled replication forks generate a distinct mutational signature in yeast

Proliferating cells acquire genome alterations during the act of DNA replication. This leads to mutation accumulation and somatic cell mosaicism in multicellular organisms, and is also implicated as an underlying cause of aging and tumorigenesis. The molecular mechanisms of DNA replication-associate...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Larsen, Nicolai B., Liberti, Sascha E., Vogel, Ivan, Jørgensen, Signe W., Hickson, Ian D., Mankouri, Hocine W.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594675/
https://ncbi.nlm.nih.gov/pubmed/28827358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706640114
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