Molecularly targeted drug combinations demonstrate selective effectiveness for myeloid- and lymphoid-derived hematologic malignancies

Translating the genetic and epigenetic heterogeneity underlying human cancers into therapeutic strategies is an ongoing challenge. Large-scale sequencing efforts have uncovered a spectrum of mutations in many hematologic malignancies, including acute myeloid leukemia (AML), suggesting that combinati...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kurtz, Stephen E., Eide, Christopher A., Kaempf, Andy, Khanna, Vishesh, Savage, Samantha L., Rofelty, Angela, English, Isabel, Ho, Hibery, Pandya, Ravi, Bolosky, William J., Poon, Hoifung, Deininger, Michael W., Collins, Robert, Swords, Ronan T., Watts, Justin, Pollyea, Daniel A., Medeiros, Bruno C., Traer, Elie, Tognon, Cristina E., Mori, Motomi, Druker, Brian J., Tyner, Jeffrey W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594650/
https://ncbi.nlm.nih.gov/pubmed/28784769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1703094114
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