DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease

The human genome contains ∼30,000 CpG islands (CGIs). While CGIs associated with promoters nearly always remain unmethylated, many of the ∼9,000 CGIs lying within gene bodies become methylated during development and differentiation. Both promoter and intragenic CGIs may also become abnormally methyl...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Proc Natl Acad Sci U S A
Main Authors: Jeziorska, Danuta M., Murray, Robert J. S., De Gobbi, Marco, Gaentzsch, Ricarda, Garrick, David, Ayyub, Helena, Chen, Taiping, Li, En, Telenius, Jelena, Lynch, Magnus, Graham, Bryony, Smith, Andrew J. H., Lund, Jonathan N., Hughes, Jim R., Higgs, Douglas R., Tufarelli, Cristina
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2017
נושאים:
PNAS Plus
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594649/
https://ncbi.nlm.nih.gov/pubmed/28827334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1703087114
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