DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease

The human genome contains ∼30,000 CpG islands (CGIs). While CGIs associated with promoters nearly always remain unmethylated, many of the ∼9,000 CGIs lying within gene bodies become methylated during development and differentiation. Both promoter and intragenic CGIs may also become abnormally methyl...

詳細記述

保存先:
書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Jeziorska, Danuta M., Murray, Robert J. S., De Gobbi, Marco, Gaentzsch, Ricarda, Garrick, David, Ayyub, Helena, Chen, Taiping, Li, En, Telenius, Jelena, Lynch, Magnus, Graham, Bryony, Smith, Andrew J. H., Lund, Jonathan N., Hughes, Jim R., Higgs, Douglas R., Tufarelli, Cristina
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2017
主題:
PNAS Plus
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594649/
https://ncbi.nlm.nih.gov/pubmed/28827334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1703087114
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